Sulindac (Sulindac)
Overview of Sulindac
Sulindac is NSAID, non-steroidal antinflammatory drug. It also possesses analgesic and antipyretic properties. Sulindac is a sulfoxide and is structurally related to Indomethacin. Sulindac is a prodrug, effective only when Sulindac is converted to a sulfide by liver enzymes. It relieves pain and reduces fever and inflammation.
Indication of Sulindac
Sulindac is primarily indicated in conditions like Acute gout, Ankylosing spondylitis, Gout, Nausea and vomiting (palliative care), Osteoarthritis, Pain, Periarticular disorder, Rheumatoid arthritis.
Contraindication of Sulindac
Sulindac is contraindicated in conditions like Peptic ulcer,GI hemorrhage.
Side Effects of Sulindac
Sulindac produces potentially life-threatening effects which include Blood dyscrasias, GI bleeding, Allergic reactions. which are responsible for the discontinuation of Sulindac therapy.,The symptomatic adverse reactions produced by Sulindac are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Drowsiness, Nausea, Constipation, Abdominal pain, Rashes, Pruritus.
Precautions of Sulindac
Sulindac should be used with caution in patients with intrinsic coagulation defects and those on anticoagulant therapy. It should be used with caution in patients with compromised cardiac function, hypertension other condition predisposing to fluid retention. It should be used with extra care in the presence of existing controlled infection. Perform periodic auditory function test during chronic therapy. Discontinue drug if skin reaction occurs.