Sulfadoxine (Sulfadoxine)
Overview of Sulfadoxine
Sulfadoxine is antibecterial, belongs to sulphonamide. Sulfadoxine is a long-acting drug with a very broad spectrum of activity Sulfadoxine is effective in the treatment of leprosy and in the prevention of malaria.
Indication of Sulfadoxine
Sulfadoxine is primarily indicated in conditions like Malaria prophylaxis, Severe falciparum malaria, Toxoplasmosis, and can also be given in adjunctive therapy as an alternative drug of choice in Cholera, Pneumonia.
Contraindication of Sulfadoxine
Sulfadoxine is contraindicated in conditions like Blood dyscrasias,Renal diseases,Hypersensitivity.
Side Effects of Sulfadoxine
The severe or irreversible adverse effects of Sulfadoxine, which give rise to further complications include Hepatitis, Pneumonitis.,Sulfadoxine produces potentially life-threatening effects which include Mucocutaneous reaction. which are responsible for the discontinuation of Sulfadoxine therapy.,The signs and symptoms that are produced after the acute overdosage of Sulfadoxine include Nausea, Vomiting, Convulsions, Excitation, Anorexia, Hematological toxicity.,The symptomatic adverse reactions produced by Sulfadoxine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Fatigue, Fever, Rashes, Stomatitis, Pruritus, Photosensitivity, Nausea and vomiting, Orthostatic hypotension, Feeling of fulness, Hepatic granulomata, Polyneuritis.
Precautions of Sulfadoxine
Sulfadoxine should be used only if clearly needed during pregnancy. It should be used with caution in patients with pre-existing blood disorders, anemia, liver disease, kidney disease, severe allergies, asthma or a history of seizures or any allergy, especially to sulfa medications.