Primaquine (Phosphate) (Primaquine (Phosphate))
Overview of Primaquine (Phosphate)
Primaquine (Phosphate) is antimalarial agent. Primaquine (Phosphate) is a synthetic 8-aminoquinoline derivative. Primaquine (Phosphate) is effective against the late hepatic stages of Plasmodium vivax and Plasmodium ovale and the primary exoerythrocytic stages of Plasmodium falciparum.
Indication of Primaquine (Phosphate)
Primaquine (Phosphate) is primarily indicated in conditions like Diagnosis of dual block due to suxamethonium, Iron deficiency anaemia, Malaria, Malaria prophylaxis, NSAID-associated gastric or duodenal ulcers (prophylaxis).
Contraindication of Primaquine (Phosphate)
Primaquine (Phosphate) is contraindicated in conditions like G6pd deficiency,Granulocytopenia.
Side Effects of Primaquine (Phosphate)
The severe or irreversible adverse effects of Primaquine (Phosphate), which give rise to further complications include Cardiac arrhythmias, Hypertension, Depression, Cyanosis.,Primaquine (Phosphate) produces potentially life-threatening effects which include Hemolytic anemia. which are responsible for the discontinuation of Primaquine (Phosphate) therapy.,The signs and symptoms that are produced after the acute overdosage of Primaquine (Phosphate) include Nausea, Vomiting, Jaundice, Hemolysis, Anorexia, Methemoglobinemia, Cyanosis, Weakness, Bone marrow suppression.,The symptomatic adverse reactions produced by Primaquine (Phosphate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Confusion, Epigastric discomfort.
Precautions of Primaquine (Phosphate)
Primaquine should be used with caution in patients with any pre-existing blood disorders, arthritis, psoriasis, lupus erythematous, glucose-6-phosphate dehydrogenase (G-6-PD) deficiency, liver disease or any allergy. It should be used only if clearly needed during pregnancy.