Primidone (Primidone)
Overview of Primidone
Primidone is a derivative of barbituric acid. Primidone is a 2-desoxyphenobarbital, was first marketed in the early 1950s. It resembles phenobarbital in its anticonvulsant activity.
Indication of Primidone
Primidone is primarily indicated in conditions like Epilepsy, Essential tumor.
Contraindication of Primidone
Primidone is contraindicated in conditions like Porphyrias.
Side Effects of Primidone
The severe or irreversible adverse effects of Primidone, which give rise to further complications include Vertigo, Ataxia, Nausea, Vomiting, Drowsiness.,Primidone produces potentially life-threatening effects which include Lupus erythematosus, Hepatitis, Dermatitis bullosa striata pratensis. which are responsible for the discontinuation of Primidone therapy.,The signs and symptoms that are produced after the acute overdosage of Primidone include Crystalluria, CNS depression, Depression of deep tendon reflexes, Flaccidity.,The symptomatic adverse reactions produced by Primidone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Sleepiness, Irritability, Ataxia, Tremors, Impotence, Loss of libido, Loss of memory, Nystagmus.
Precautions of Primidone
Perform complete blood counts test after every 6 months because therapy generally extends over prolonged period.