Estradiol. (Estradiol.)
Overview of Estradiol.
Estradiol is a naturally occuring sex hormone (oestrogen). estradiol is used along with progesterone for contraception, menstrual disorder, and for the suppression of certain cancers and also for the prevention of osteoporosis.
Indication of Estradiol.
Estradiol. is primarily indicated in conditions like Menopausal symptoms, Prostatic cancer.
Contraindication of Estradiol.
Estradiol. is contraindicated in conditions like Hypertension,Vaginal bleeding,Porphyrias,Cardiovascular disease,Oestrogenic sarcoma,Cerebrovascular disease,Haemoglobinopathies,Hyperlipoproteinaemia.
Side Effects of Estradiol.
The severe or irreversible adverse effects of Estradiol., which give rise to further complications include Irritability, Gynacomastia, Uterine bleeding, Tachyphylaxis.,Estradiol. produces potentially life-threatening effects which include Breast cancer, Endometrial carcinoma. which are responsible for the discontinuation of Estradiol. therapy.,The signs and symptoms that are produced after the acute overdosage of Estradiol. include Vomiting, Dizziness, Headache, Speech problem, Breast Lump, Redness in one leg, Chest crushing pain, Shortness of breath, Double Vision, Coughing up blood.,The symptomatic adverse reactions produced by Estradiol. are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Depression, Weight gain, Nausea and vomiting, Fluid retention, Breast tenderness.
Precautions of Estradiol.
High doses of estrogen used in treatment of malignant disease should be used cautiously in patients with cerebrovascular disorder, coronary artery disease or venous thromboembolism. Estrogens should be used with caution in children, because premature closure of epiphysis may occur resulting in inhibited linear growth and small stature.