Ofloxacin (Ofloxacin)
Overview of Ofloxacin
It is of Semi Synthetic origin and belongs to Quinolone. It belongs to DNA Gyrase inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Quinolone pharmacological group
Indication of Ofloxacin
Ofloxacin is primarily indicated in conditions like Acute uncomplicated cystitis, Bronchitis, Chronic prostatitis, Complicated UTIS, Corneal ulcers, Diabetic foot ulcer, GI infections, Lower RTIs, Meningococal infections, Opthalmic infections, Otitis externa, Otitis media, Pelvic inflammatory disease, Pneumonia, Prostatitis, Pulmonary infection, Septicaemia, Sexually transmitted infections, Skin and soft tissue infections, Travelers diarrhoea, Uncomplicated genital chlamydial infection, non-gonococcal urethritis, Urinary tract infection, and can also be given in adjunctive therapy as an alternative drug of choice in Conjuctivitis, Osteomyelitis, Skin infections, Soft tissue infections.
Contraindication of Ofloxacin
Ofloxacin is contraindicated in conditions like Hypersensitivity.
Side Effects of Ofloxacin
The severe or irreversible adverse effects of Ofloxacin, which give rise to further complications include Sinus tachycardia, Hallucinations, Hallucinations, Stevens johnson syndrome, Stevens johnson syndrome, Seizures, Tendon rupture.,Ofloxacin produces potentially life-threatening effects which include Agranulocytosis, Anaphylaxis. which are responsible for the discontinuation of Ofloxacin therapy.,The symptomatic adverse reactions produced by Ofloxacin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Vomiting, Diarrhea, Insomnia, Abdominal pain, Pruritus, Photosensitivity, GI upset, Hypotension, dizziness, Hypotension.
Precautions of Ofloxacin
Ofloxacin should be used with caution in patients with epilepsy, kidney disease, tendon problems, nervous system disorders, liver disease and of any allergies, including drug allergies. It should be used with caution while driving or performing tasks requiring alertness because this medication causes dizziness, lightheaded or drowsiness. Limit alcohol intake. Because this increase sensitivity to the sun, avoid prolonged sun exposure, wear protective clothing and use a sunscreen when outdoors. Caution is advised when used in children under 18 years of age. It should be used only when clearly needed during pregnancy. Avoid use during lactation. Prolonged use may result in overgrowth of non-susceptible organisms. Caution is required in patients hypersensitive to other quinolones. Care is also required as ofloxacin is systemically absorbed after topical administration.