Octreotide acetate (Octreotide acetate)
Overview of Octreotide acetate
Octreotide (Acetate) is a parenteral synthetic analogue of the naturally occurring hormone somatostatin. The activity of octreotide is similar to that of somatostatin. Octreotide, however, has a longer half-life, greater selectivity for inhibiting glucagon, growth hormone, and insulin release, and a lower incidence of rebound hypersecretion following discontinuation. Based on this activity, octreotide has been approved for use in controlling the symptoms associated with vasoactive intestinal peptide tumors (VIPomas; watery diarrhea) and metastatic carcinoid tumors (flushing and diarrhea). Other non-approved uses of octreotide include AIDS-associated diarrhea, esophageal varices, and pituitary tumors (i.e., acromegaly and thyrotropinomas).
Indication of Octreotide acetate
Octreotide Acetate is primarily indicated in conditions like Acromegaly, Adjunct in ganciclovir treatment, Carcinoid tumours, Glucagonoma, Hormone-mediated secretory diarrhea, To reduce intestinal secretions and vomiting (palliative care), Variceal bleeding, Vipoma, and can also be given in adjunctive therapy as an alternative drug of choice in Acromegaly (short-term treatment before pituitary surgery), Hormone-mediated secretory diarrhea (can be benefit in refactory cases), Symptoms associated with carcinoid tumours, To reduce intestinal secretions and vomiting.
Contraindication of Octreotide acetate
No data regarding the contra indications of Octreotide (Acetate) is available.
Side Effects of Octreotide acetate
The severe or irreversible adverse effects of Octreotide (Acetate), which give rise to further complications include Gall stones.,Octreotide (Acetate) produces potentially life-threatening effects which include Hypoglycemia, Hypoglycemia, Hypoglycemia, Hepatic dysfunction, Acute pancreatitis. which are responsible for the discontinuation of Octreotide (Acetate) therapy.,The symptomatic adverse reactions produced by Octreotide (Acetate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flatulence, Loose stools, Anorexia, Abdominal pain, Pain, Local pain, Local reactions, Nausea and vomiting, Tingling, Steatorrhea, Tenderness, Bloating, Stinging.
Precautions of Octreotide acetate
Octreotide should be used with caution in patients with kidney disease, diabetes, any other illness or any allergy. Check should be made for gallstone before prolonged therapy and at 6 to 12 months interval during treatment.