Nystatin (Nystatin)
Overview of Nystatin
Nystatin is antifungal agent obtained from Streotomyces noursei. It was one of the first polyene antibiotic of undetermined structure, discovered and used clinicaly. It acts as a fungistatic and fungicidal and active against most Candida species. Nystatin is a mixture of four different tetranes, primarily it A1, along with two other tetranes A2 or A3 and polyfungin B. Nystatin is very toxic for parentral administration and is only used topically.
Indication of Nystatin
Nystatin is primarily indicated in conditions like Candidiasis, Fungal infection, Intestinal candidiasis, Oral and perioral fungal infections, and can also be given in adjunctive therapy as an alternative drug of choice in Vaginal infections.
Contraindication of Nystatin
No data regarding the contra indications of Nystatin is available.
Side Effects of Nystatin
The signs and symptoms that are produced after the acute overdosage of Nystatin include Nephrotoxicity.,The symptomatic adverse reactions produced by Nystatin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Diarrhea, Abdominal pain, Rashes, Urticaria, Skin irritation, Contact dermatitis, Stevens Johnson syndrome, Contact dermatitis, rashes.
Precautions of Nystatin
Nystatin should be used cautiously in patients with paraben hypersensitivity and in diabetes mellitus patients. It is classified as pregnancy category C drug and should be used during pregnancy only if clearly needed.