Nicoumalone (Nicoumalone)
Overview of Nicoumalone
Nicoumalone is an anticoagulant, with actions, interactions and adverse effects similar to warfarin.
Indication of Nicoumalone
Nicoumalone is primarily indicated in conditions like Deep vein thrombosis, Duodenal errosions, Myocardial infarction, Prevention of thrombosis, Prophylaxis of embolisation, Prosthetic heart valves, Pulmonary embolism, Rheumatic heart disease.
Contraindication of Nicoumalone
Nicoumalone is contraindicated in conditions like Haemorrhage,Cerebrovascular disease.
Side Effects of Nicoumalone
The severe or irreversible adverse effects of Nicoumalone, which give rise to further complications include Skin necrosis.,Nicoumalone produces potentially life-threatening effects which include Hemorrhage, GI bleeding, Hematuria, Bruising, Hemorrhage. which are responsible for the discontinuation of Nicoumalone therapy.,The signs and symptoms that are produced after the acute overdosage of Nicoumalone include Bleeding.
Precautions of Nicoumalone
Nicournalone should be used with caution in patients with ulcers, unusual menstrual periods, diabetes, liver or kidney disease, high blood pressure, arthritis, thyroid problems, all recent infections, if have had recent surgery or of drug and food allergies. If patient have an illness that causes vomiting, diarrhea or fever for more than a few days, contact the doctor as these problems can change the effect of drug. Limit consumption of alcoholic beverages. Avoid sudden changes in dietary habits, Avoid ingesting unusual increases or decreases of foods high in Vitamin K (e.g.liver, cauliflower, cabbage, spinach and other green leafy vegetables, green tea, certain vegetables, cheeses and certain vitamin supplements). It is best to avoid strictly vegetarian diets that consist of foods high in vitamin K. Be extra careful to avoid injuries, because this medication can cause heavy bleeding. Be careful while brushing teethes or use an electric razor. It should not be used during pregnancy. It should be used with caution during lactation.