Metolazone (Metolazone)
Overview of Metolazone
Metolazone is a thiazide related diuretic. Metolazone is a quinazolinone derivative prepared by chemical synthesis. Metolazone is optically active and used as a racemate clinically. Metolazone is given orally. Metolazone is a sulfonamide derivative that has different chemical structure but the possess same pharmacological actions as the thiazide diuretics.
Indication of Metolazone
Metolazone is primarily indicated in conditions like Congestive heart failure, Edema, Hepatic disease, Hypertension, Oedema, Renal failure.
Contraindication of Metolazone
Metolazone is contraindicated in conditions like Diabetes mellitus,Ventricular arrhythmias.
Side Effects of Metolazone
The severe or irreversible adverse effects of Metolazone, which give rise to further complications include Hypokalemia, Hyperglycemia, Hyperglycemia.,The signs and symptoms that are produced after the acute overdosage of Metolazone include Dizziness, Nausea & vomiting, Weakness.,The symptomatic adverse reactions produced by Metolazone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Palpitation, Constipation, Chills, Rashes, VertigoX, Muscle cramps, Nocturia, Chest pain.
Precautions of Metolazone
Thiazide diuretics increase sensitivity to sunlight, avoid prolonged sun exposure, use a sunscreen and wear protective clothing. This should be used during pregnancy or lactation only if clearly needed. Metolazone should be used with caution in patients with gout or diabetes or any allergy especially to sulfa medications. Avoid any drug that increases heart rate or cause excitation like decongestants (found in cough or cold products) because it may counter-act blood pressure medicine.