Chlorprothixene (Chlorprothixene)
Overview of Chlorprothixene
Chlorprothixene is a thioxanthene drug having sedative, antiemetic, antihistaminic, anticholinergic and a-adrenergic blocking activity. Chlorprothixene is administered orally or by intramuscular injection.
Indication of Chlorprothixene
Chlorprothixene is primarily indicated in conditions like Agitation, Mania, Psychosis, Schizophrenia, and can also be given in adjunctive therapy as an alternative drug of choice in Anxiety, Herpetic neuralgia.
Contraindication of Chlorprothixene
Chlorprothixene is contraindicated in conditions like Circulatory collapse,Coma.
Side Effects of Chlorprothixene
The severe or irreversible adverse effects of Chlorprothixene, which give rise to further complications include Tardive dyskinesia, Seizures, Systemic lupus erythematosus.,Chlorprothixene produces potentially life-threatening effects which include Obstructive Jaundice, Neuroleptic Malignant Syndrome, Neuroleptic malignant syndrome. which are responsible for the discontinuation of Chlorprothixene therapy.,The signs and symptoms that are produced after the acute overdosage of Chlorprothixene include Hypotension, Tachycardia, Cardiac arrhythmias, Seizures, Cardiodepression, Respiratory arrest, Reduced peristalsis of GIT, Acute oliguria.,The symptomatic adverse reactions produced by Chlorprothixene are more or less tolerable and if they become severe, they can be treated symptomatically, these include Skin rashesX, Sedation, Parkinsonism, Akathisia, Hypotension, Nausea and vomiting, Acute dystonia, Induction of hostility, Extra pyramidal symptoms.
Precautions of Chlorprothixene
Chlorprothixene should be used with caution in patients exposed to extreme heat or phosphorus insecticides, patients in state of alcohol withdrawal, patients with history of peptic ulcer, allergic reactions, with renal impairment, prostatic hypertrophy. Photosensitization may occur, caution patients to take appropriate measure (e.g.wear protective clothing or sunscreen) against exposure to sunlight or UV light. Discontinue use atleast 48 hours before myelography.