Chlorpropamide (Chlorpropamide)
Overview of Chlorpropamide
Chlorpropamide is oral hypoglycemic agent. Chlorpropamide is used in the treatment of non-insulin dependent diabetes mellitus. Chlorpropamide is used in conjunction with proper diet and exercise to decrease blood sugar levels.
Indication of Chlorpropamide
Chlorpropamide is primarily indicated in conditions like Diabetes insipidus, Diabetes mellitus, Diabetes mellitus type-ii, and can also be given in adjunctive therapy as an alternative drug of choice in Softening and dilatation of cervix before mechanical cervical dilatation.
Contraindication of Chlorpropamide
Chlorpropamide is contraindicated in conditions like Iddm,Ketosis,Congestive heart failure,Renal impairment,Hepatic impairment,Gestational diabetes mellitus.
Side Effects of Chlorpropamide
The severe or irreversible adverse effects of Chlorpropamide, which give rise to further complications include Thrombocytopenia, Cholestatic jaundice, Aplastic anemia, Hemolytic anemia, Cholestatic jaundice, Aplastic anemia, Hemolytic anemia, Fictitious hypoglycemia, Agranulocytosis, Exfoliative dermatitis, Eosinophilic pulmonary infiltrates, Hemolytic anemia, Aplastic anemia.,Chlorpropamide produces potentially life-threatening effects which include Hypoglycemia, Hypoglycemia, Hypoglycemia. which are responsible for the discontinuation of Chlorpropamide therapy.,The signs and symptoms that are produced after the acute overdosage of Chlorpropamide include Coma, Seizures, Hypothermia, Hypoglycemia.,The symptomatic adverse reactions produced by Chlorpropamide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Diarrhea, Abdominal pain, Dyspepsia, Facial flushing, Hyponatremia, dyspepsia.
Precautions of Chlorpropamide
Chlorpropamide should be used with caution in patients with medical history, especially if have high blood pressure or liver or kidney disease. Avoid alcohol while taking this medication. Photosensitization may occur, caution patients to take appropriate measure (e.g.wear protective clothing and a sunscreen) against exposure to UV or sunlight. It should be used in pregnancy or lactation only if clearly needed. Insulin therapy may be necessary during pregnancy.