Chlorpromazine Hcl (Chlorpromazine Hcl)
Overview of Chlorpromazine Hcl
Chlorpromazine Hcl is the hydrochloride salt of chlorpromazine which is a phenothiazine derivative. It is used as an antiemetic, antipsychotic and tranquilizer. Chlorpromazine Hcl is administered by rectal suppositories.
Indication of Chlorpromazine Hcl
Chlorpromazine Hcl is primarily indicated in conditions like Agitation, Agitation and restlessness in the elderly, Autism, Childhood schizophrenia, Conduct disorder with hyperactivity, Control of agitated states in elderly without confusion, Enhance permeation of SC or IM inj, Hiccup due to gastric distension in palliative care, Induction of labour, Intractable hiccup, Locally advanced or metastatic pancreatic cancer, Mania, NSAID-associated gastric and duodenal ulcers, Prevention and treatment of haemorrhage due to incomplete abortion, Prevention of vascular headache, Prostate cancer, Psychosis, Renal function testing, Rhinitis, Schizophrenia and other psychoses, and can also be given in adjunctive therapy as an alternative drug of choice in Comatose states, Hiccup, Induction of hypothermia, Muscular spasm, Nausea and vomiting, Porphyria, Pre-operative sedation, Restlessness and confusion in palliative care.
Contraindication of Chlorpromazine Hcl
Chlorpromazine (HCl) is contraindicated in conditions like Epilepsy,Myasthenia gravis,Narrow-angle glaucoma,Parkinson's disease,Depressed level of conciousness.
Side Effects of Chlorpromazine Hcl
The severe or irreversible adverse effects of Chlorpromazine (HCl), which give rise to further complications include Cholestatic jaundice, Cholestatic jaundice, Photosensitivity, Paralytic ileus, Impotence, Blood dyscrasias, Gynecomastia, Respiratory failure, bilirubinemia, icterus, blood dyscrasias.,Chlorpromazine (HCl) produces potentially life-threatening effects which include Seizures, Blood dyscrasias, Neuroleptic Malignant Syndrome, Temperature disorders, Neuroleptic malignant syndrome, Ventricular arrhythmias, Jaundice, Tradive dyskinesia. which are responsible for the discontinuation of Chlorpromazine (HCl) therapy.,The signs and symptoms that are produced after the acute overdosage of Chlorpromazine (HCl) include Hypotension, Tachycardia, Coma, Hypothermia, Tachypnea, Decreased diastolic BP, Somnolence.,The symptomatic adverse reactions produced by Chlorpromazine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Drowsiness, Constipation, Insomnia, Skin rashes, Dry mouth, Blurred vision, Allergic reactions, Akathisia, Nasal stiffiness, Weight gain, Diaphoresis, Acute dystonia, Skin pigmentation, Faintness, Decrease in libido, Galactorrhea, HyperprolactinemiaX, Adverse behavioral reactions, Amenorrhea, Xerostomia, Ocular complicaions, Urinary retention, Dry mouth, Skin rashes, dizziness, faintness, Palpitations, anticholnergic efforts, worsening of glaucoma.
Precautions of Chlorpromazine Hcl
Chlorpromazine should be used with caution in patients exposed to extreme heat or phosphorus insecticides, patients in state of alcohol withdrawal, patients with history of peptic ulcer, allergic reactions, with renal impairment, prostatic hypertrophy. Photosensitization may occur, caution patients to take appropriate measures (e.g.wear protective clothing or sunscreen) against exposure to sunlight or ultra violet light. Discontinue use atleast 48 hours before myelography.