Tibolone (Tibolone)
Overview of Tibolone
Tibolone is a steroid that has oestrogenic, progestogenic, and weak androgenic properties. Tibolone is used as a menopausal hormone replacement therapy in the treatment of menopausal vasomotor symptoms and the prevention of post-menopausal osteoporosis.
Indication of Tibolone
Tibolone is primarily indicated in conditions like Menopausal symptoms, Osteoporosis, Osteoporosis prophylaxis, Sedation with amnesia.
Contraindication of Tibolone
Tibolone is contraindicated in conditions like Vaginal bleeding,Liver diseases,Thromboembolism,Cardiovascular disease,Cerebrovascular disease.
Side Effects of Tibolone
The symptomatic adverse reactions produced by Tibolone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Abdominal pain, Rashes, Pruritus, Weight gain, Edema, Migraine.
Precautions of Tibolone
Tibolone is not recommended for use in women with hormone-dependant tumors, cardiovascular or cerebrovascular disorders, undiagnosed vaginal bleeding or severe liver disorders. It should not be given to pregnant or lactating women and should not be used prior to the menopause because menstrual regularity may be disturbed. Use of tibolone within 12months of a natural menopause is not recommended. It should be used with caution in patients with disorders that may be exacerbated by fluid retention such as kidney dysfunction, epilepsy or migraine, hypercholesterolaemia and impaired glucose tolerance. Discontinue use if there is sign of thrombo-embolism or if abnormal liver function tests or cholestatic jaundice occur.