Nitroglycerin (Nitroglycerin)
Overview of Nitroglycerin
Nitroglycerin is an organic nitrate, first synthesized in 1846, but not recognized to have antianginal effects until 1879. Chemically Nitroglycerin is 1, 2, 3-propanetriol trinitrate. Nitroglycerin is a vasodilator, available in many dosage forms, proven to be the mainstay of therapy in the management of angina pectoris. Nitroglycerin is also used to control perioperative hypertension, to produce controlled hypotension during surgical procedures, to treat hypertensive emergencies, and to treat congestive heart failure associated with myocardial infarction. The use of sublingual nitroglycerin for the relief of acute anginal attacks was established in 1879. Because Nitroglycerin is inexpensive, has a rapid onset of action, and has a well-documented efficacy, sublingual nitroglycerin is still considered the drug of choice for the acute relief of angina. Nitroglycerin was granted FDA approval in 1938.
Indication of Nitroglycerin
Nitroglycerin is primarily indicated in conditions like Angina pectoris, Heart failure, Myocardial infarction (non st-segment elevation).
Contraindication of Nitroglycerin
Nitroglycerin is contraindicated in conditions like Myocardial infarction,Increase intracranial pressure,Hypersensitivity to any component of product.
Side Effects of Nitroglycerin
The symptomatic adverse reactions produced by Nitroglycerin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Vomiting, Restlessness, Palpitation, Skin rashes, Dry mouth, Blurred vision, Flushing, Contact dermatitis, Local irritation, Dry mouth, Skin rashes, dizziness, Contact dermatitis.
Precautions of Nitroglycerin
Before using this medication tell your doctor your medical history especially of: heart problems, head injury or surgery, glaucoma, thyroid conditions, anemia, alcohol usage, allergies (especially allergies to drugs or adhesives). Use caution engaging in activities that require alertness or in operating machinery if this medication makes you dizzy or drowsy. Alcoholic beverages may increase the risk of fainting or of experiencing dizziness. This medication should be used during pregnancy only if clearly needed. Discuss the risks and benefits with your doctor. It is not known if this drug is excreted into breast milk. Consult your doctor before breast-feeding.