Nitrofurazone (Nitrofurazone)
Overview of Nitrofurazone
Nitrofurazone is a local antibacterial agent, effective against a wide variety of gram positive and gram negative oragnisms. Nitrofurazone is used topically in the treatment of mixed, superficial infection of skin. Nitrofurazone is effective especially in the treatment of second and third degree burns and in skin grafting. Nitrofurazone is slowly acting drug and atleast 24 hours are required for it to take effect properly. Therefore, no treatment should be less than 2 or 3 days in duration.
Indication of Nitrofurazone
Nitrofurazone is primarily indicated in conditions like Bacterial infections, Bladder irrigation, Burns and ulcers, Dermatosis, Otitis media, Skin infections, Wounds.
Contraindication of Nitrofurazone
Nitrofurazone is contraindicated in conditions like Renal impairment.
Side Effects of Nitrofurazone
The severe or irreversible adverse effects of Nitrofurazone, which give rise to further complications include Peripheral neuropathy, Thromboembolic disorder.,The symptomatic adverse reactions produced by Nitrofurazone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Vomiting, Dyspnea, Pain, Depression, Chest pain, Shortening of breath, Allergic skin reactions, Loss of vision, Calf pain, Numbness or weakness in extremity, Vision disturbances.
Precautions of Nitrofurazone
Because of the risk of haemolysis, nitrofurazone by mouth should be used with caution in patients with glucose-6-phosphate dehydrogenase deficiency. Avoid use topical nitrofurazone in patients with known hypersensitivity. Preparations containing macrogil should be used with caution in renal impairment.