Bretylium Tosylate (Bretylium Tosylate)
Overview of Bretylium Tosylate
Bretylium (Tosylate) is a potassium channel blocking agent. Bretylium (Tosylate) is a quaternary salt and is an adrenergic neurona blocking agent. It was first introduced as an antihypertensive agent.Bretylium (Tosylate) is now used as an antiarrhythmic agent. It interferes with the neuronal release of catecholamines but also has direct antiarrhythmic properties.
Indication of Bretylium Tosylate
Bretylium Tosylate is primarily indicated in conditions like Prophylaxis of acid aspiration in obstetrics, Ventricular arrhythmias.
Contraindication of Bretylium Tosylate
Bretylium (Tosylate) is contraindicated in conditions like Cardiac arrhythmia,Myocardial infarction,Digitalis induced arrythmias.
Side Effects of Bretylium Tosylate
Bretylium (Tosylate) produces potentially life-threatening effects which include Hypotension. which are responsible for the discontinuation of Bretylium (Tosylate) therapy.,The signs and symptoms that are produced after the acute overdosage of Bretylium (Tosylate) include Severe hypotension.,The symptomatic adverse reactions produced by Bretylium (Tosylate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Facial flushing, Transient increase in blood pressure, Parotid pain and swelling, Transient diplopia, Nausea and vomiting.
Precautions of Bretylium Tosylate
Increase dose interval of bretylium in renal dysfunction. Dilute for IV use except in treating existing ventricular fibrillation where it should be given as rapidly as possible.