Sulbactam (Sulbactam)
Overview of Sulbactam
Sulbactam is a beta lactamase inhibitor. It does not have significant antibacterial activity, rather it binds and inactivates ß- lactamases (the family of enzymes hydrolyzes the cyclic amide bond of ß-lactam ring, which result in loss of bactericidal activity), thereby protecting antibiotics that are normally the substrates of these enzymes. Sulbactam is used with penicillins and other ß-lactam antibiotics to protect them from enzymatic inactivation.
Indication of Sulbactam
Sulbactam is primarily indicated in conditions like Beta lactamase resistant pseudomonas, Gynecological infections, Intra-abdominal infections, Methicillin resistant staphylococci, Skin infections.
Contraindication of Sulbactam
Sulbactam is contraindicated in conditions like Hypersensitivity.
Side Effects of Sulbactam
The severe or irreversible adverse effects of Sulbactam, which give rise to further complications include Exfoliative dermatitis, Bone marrow depression.,Sulbactam produces potentially life-threatening effects which include Anaphylaxis. which are responsible for the discontinuation of Sulbactam therapy.,The signs and symptoms that are produced after the acute overdosage of Sulbactam include Seizures.,The symptomatic adverse reactions produced by Sulbactam are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Fatigue, Abdominal pain, Dysuria, Malaise, Glossitis, Urinary RetentionX, Epistaxis, Urinary retention.
Precautions of Sulbactam
Sulbactam should be used with caution in patients with illnesses or any allergy especially to penicillin or other antibiotics. In diabetic patients, this can affect the results of clinitest tablets. This may interfere with oral contraceptives, if using oral contraceptives discuss with doctor alternate birth control methods to use, while using this medication. It should be used only if clearly needed during pregnancy or lactation.