Alendronate Na (Alendronate Na)
Overview of Alendronate Na
Alendronate (Na) is aminobisphosphonate and inhibitor of osteoclast-mediated bone resorption. Chemically Alendronate (Na) is identified as (4-Amino-1-hydroxybutylidene)-bisphosphonic acid monosodium salt trihydtare. Alendronate (Na) is prepared by chemical synthesis. Alendronate (Na) is effective to treat osteoporosis (bone thinning) by increasing bone density in post menopausal women. At the cellular level, Alendronate (Na) shows preferential localization to sites of bone resorption, specifically under osteoclasts. The osteoclasts adhere normally to the bone surface but lack the ruffled border that is indicative of active resorption. Alendronate (Na) does not interfer with osteclast recruitment or attachment, but it does inhibit osteoclast activity. While incorporated in bone matrix, Alendronate (Na) is not pharmacologically active. Thus Alendronate (Na) must be continuously administered to suppress osteoclasts on newly formed resorption surface. Alendronate (Na) is administered orally.
Indication of Alendronate Na
Indications
Contraindication of Alendronate Na
Contraindications
Side Effects of Alendronate Na
Side Effects
Precautions of Alendronate Na
Precautions