Acitretin (Acitretin)
Overview of Acitretin
Acitretin is orally absorbed retinoid. Acitretin is made by chemical synthesis. Acitretin is effective in the treatment of severe psoriasis and other serious disorders of skin growth.
Indication of Acitretin
Acitretin is primarily indicated in conditions like Congenital ichthyosis, Dariers disease, Psoriasis, and can also be given in adjunctive therapy as an alternative drug of choice in Dermatosis, Discoid lupus erythematosus, Granuloma annulare.
Contraindication of Acitretin
Acitretin is contraindicated in conditions like Depression,Diabetes mellitus,Hyperlipidemia,Hypervitaminosis.
Side Effects of Acitretin
The severe or irreversible adverse effects of Acitretin, which give rise to further complications include Seizures, Osteoporosis, Exostosis, Corneal opacity, Skeletal hyperostoses.,The signs and symptoms that are produced after the acute overdosage of Acitretin include Hepatic enzyme disturbance, Erythema.,The symptomatic adverse reactions produced by Acitretin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Alopecia, Myalgia, Pruritus, Erythema, Dryness of mouth, Depression, Arthralgia, Fragility of skin, Cheilitis, Conjunctivitis, Sore throat, Vasculitis, Voice disturbance, Elevated SGPT & SGOT, Epistaxis, Elevated serum triglyceride.
Precautions of Acitretin
Use with caution in patients with kidney disease, liver disease, heart disease, diabetes or if have any drug allergies. It is recommended that persons taking this medication should not donating blood for at least three years after stopping therapy. This medication increases sensitivity to the sun, so wear protective clothing and use a sunscreen before exposure to UV or sunlight. Avoid drinking alcohol while taking this medication and for two months after stopping the drug. This drug should not be used during pregnancy and lactation.