Phenoxybenzamine Hcl (Phenoxybenzamine Hcl)
Overview of Phenoxybenzamine Hcl
Phenoxybenzamine Hcl is irreversible a-adrenergic blocking agent, with a non-selective, covalent biniding with both a1 post-synaptic and a2 presynaptic receptors.Chemically related to nitrogen mustard. it has a long duration of action. Phenoxybenzamine Hcl is used to control hypertension and sweating in pheochromocytoma, to treat Raynaud`s phenomenon, to treat micturation disorders resulting from neurogenic bladder dysfunction.
Indication of Phenoxybenzamine Hcl
Phenoxybenzamine Hcl is primarily indicated in conditions like Adjunct in hypertensive episodes in pheochromocytoma, Hypertension, Hypertensive episodes in phaeochromocytoma, Phaeochromocytoma, and can also be given in adjunctive therapy as an alternative drug of choice in Raynaud's phenomenon, Urinary obstruction.
Contraindication of Phenoxybenzamine Hcl
Phenoxybenzamine (HCl) is contraindicated in conditions like Orthostatic hypotension,Fluid depletion.
Side Effects of Phenoxybenzamine Hcl
The severe or irreversible adverse effects of Phenoxybenzamine (HCl), which give rise to further complications include Postoperative hypotension.,Phenoxybenzamine (HCl) produces potentially life-threatening effects which include Postural hypotension. which are responsible for the discontinuation of Phenoxybenzamine (HCl) therapy.,The symptomatic adverse reactions produced by Phenoxybenzamine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Lethargy, Sedation, Nasal stiffiness, Nausea and vomiting, Miosis, Ejaculatory failure.
Precautions of Phenoxybenzamine Hcl
Phenoxybenzamine should be used with caution in patients with marked cerebral or coronary arteriosclerosis or renal (kidney) damage.