Vincristine sulphate (Vincristine sulphate)
Overview of Vincristine sulphate
Vincristine (Sulphate) is antineoplastic (anticancer) drug. Vincristine (Sulphate) is alkaloid derivative of Vinca rosea, the periwinkle plant. Structurally Vincristine (Sulphate) is a complexed compound and differ from vinblastine only in having an aldehyde moiety. Vinblastine is an alkaloid extracted from the periwinkle plant. Vincristine (Sulphate) is a parenteral, cell cycle-phase specific antineoplastic agent used in the management of breast carcinoma, bladder carcinoma, Hodgkin's disease, melanoma, and testicular carcinoma. Vincristine is similar to vinblastine in action, but their toxicities differ significantly. Vincristine was approved by the FDA in 1961. Vincristine (Sulphate) is used in combination of different anticancer drugs to obtain best therapeutic effect and minimize side effects or toxicity.
Indication of Vincristine sulphate
Indications
Contraindication of Vincristine sulphate
Vincristine (Sulphate) is contraindicated in conditions like Bronchospasm,Jaundice,Marie tooth syndrome.
Side Effects of Vincristine sulphate
The severe or irreversible adverse effects of Vincristine (Sulphate), which give rise to further complications include GI symptoms, Neurotoxicity.,The signs and symptoms that are produced after the acute overdosage of Vincristine (Sulphate) include Myelosuppression.,The symptomatic adverse reactions produced by Vincristine (Sulphate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Vomiting, Alopecia, Diarrhea, Fever, Constipation, Weight loss.
Precautions of Vincristine sulphate
Vincristine is not recommended for use in pregnant or nursing women. Contraceptive measures are recommended for use in men or women when taking this drug. It can lower body's ability to fight an infection, consult the doctor if any sign of an infection such as fever, sore throat, rash or chills appear. Do not have immunizations or vaccinations without consent of doctor and avoid contact with people who have recently received oral polio vaccine.