Vigabatrin (Vigabatrin)
Overview of Vigabatrin
Vigabatrin is anticonvulsant agent. Vigabatrin is analogue of GABA (gamma amino-butyric acid). GABA is an inhibitory neurotransmitter, which is thought to be deficient in epilepsy, and able to stabilise discharges from epileptic foci. Vigabatrin is used in treatment of epilepsy, especially when not controlled by other drugs.
Indication of Vigabatrin
Vigabatrin is primarily indicated in conditions like Epilepsy, Infantile spasms, and can also be given in adjunctive therapy as an alternative drug of choice in Iron deficiency anaemia.
Contraindication of Vigabatrin
Vigabatrin is contraindicated in conditions like Ventricular arrhythmias resistant to other treatment.
Side Effects of Vigabatrin
The signs and symptoms that are produced after the acute overdosage of Vigabatrin include Coma, Unconsciousness, Tremor, Vertigo.,The symptomatic adverse reactions produced by Vigabatrin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Fatigue, Irritability, Ataxia, Nervousness, Confusion, Depression, Psychosis, Diplopia, SomnolenceX.
Precautions of Vigabatrin
Vigabatrin should be used with caution during pregnancy. It should be used with caution in elderly and patient with renal (kidney) impairment. Care is required when withdrawing vigabatrin therapy. Caution is warranted in patients with history of psychosis or behavioral problems.