Trimethoprim (Trimethoprim)
Overview of Trimethoprim
Trimethoprim is a synthetic antibacterial agent, closely related to the antimalarial agent pyrimethamine. Chemically Trimethoprim is trimethoxybenzylpyrimidine. It has activity against both gram-positive and gram-negative bacteria. Trimethoprim is commonly used systemically for the treatment and prophylaxis of uncomplicated urinary tract infections, for traveler's diarrhea, and, when combined with either sulfamethoxazole or dapsone, for prophylaxis and treatment of Pneumocystis carinii infections. It was originally made available in combination with sulfamethoxazole in 1973, then was approved by the FDA for use as a single agent in 1980. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the drug at regular intervals of time throughout the day and night as prescribed. Trimethoprim is important to take the drug for the full time period as prescribed. Discontinuation of the drug, may result in ineffective treatment.
Indication of Trimethoprim
Trimethoprim is primarily indicated in conditions like Benign gastric and duodenal ulceration and chronic gastritis, Prophylaxis of NSAID-induced gastric and duodenal ulceration, Prophylaxis of UTI, Respiratory tract infections, UTI.
Contraindication of Trimethoprim
Trimethoprim is contraindicated in conditions like Impaired renal function,Haematological disorders.
Side Effects of Trimethoprim
The signs and symptoms that are produced after the acute overdosage of Trimethoprim include Vomiting, Depression, Psychosis, Mania, Facial edema.
Precautions of Trimethoprim
Trimethoprim should be used with caution in patients with kidney disease, any anemia or any drug allergy. Trimethoprim should be used during pregnancy only if clearly needed. Avoid use during lactation.