Bethanidine sulphate (Bethanidine sulphate)
Overview of Bethanidine sulphate
Bethanidine (Sulphate) is used in hypertension to reduce the blood pressure.its actions and uses are similar to those of guanethidine monosulphate but it causes less depletion of noradrenaline stores. It also has a more rapid onset, together with a shorter duration of action, than guanethidine.
Indication of Bethanidine sulphate
Bethanidine Sulphate is primarily indicated in conditions like Hypertension.
Contraindication of Bethanidine sulphate
Bethanidine (Sulphate) is contraindicated in conditions like Phaeochromocytoma,Renal failure.
Side Effects of Bethanidine sulphate
The severe or irreversible adverse effects of Bethanidine (Sulphate), which give rise to further complications include Diarrhoea, Thrombocytopenia, Impotence.,Bethanidine (Sulphate) produces potentially life-threatening effects which include Severe Hypotension, Myocardial infarction, Angina pectoris, Cerebrovascular insufficiency, Syncope, Cerebral infarction. which are responsible for the discontinuation of Bethanidine (Sulphate) therapy.,The signs and symptoms that are produced after the acute overdosage of Bethanidine (Sulphate) include Bradycardia, Postural hypotension, Dizziness, Fainting.,The symptomatic adverse reactions produced by Bethanidine (Sulphate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Vomiting, Nasal stiffiness.
Precautions of Bethanidine sulphate
Bethanidine (beta-blocker) should not be given to patients with bronchospasm, asthma, with history of obstructive airway disease, metabolic acidosis, partial heart block, sinus bradycardia or psoriasis. The dose may need to reduce in patients with renal (kidney) or hepatic (liver) dysfunction. Patients with long term treatment with beta-blockers should have their medication discontinued gradually over a period of 1 to 2 weeks, because it may result in angina, myocardial infraction (MI), ventricular arrhythmia or death. This drug should be used only if clearly needed during pregnancy or lactation.