Sumatriptan (Sumatriptan)
Overview of Sumatriptan
Sumatriptan (Succinate) is a 5-HT 1 agonist. Sumatriptan (Succinate) is given orally or parenterally in acute migraine attacks. It reduces the dilatation of blood vessels associated with throbbing headache. Sumatriptan (Succinate) is not for the prophylaxis of migraine.
Indication of Sumatriptan
Sumatriptan is primarily indicated in conditions like Cluster headache, Migraine, Treatment of acute migraine attacks.
Contraindication of Sumatriptan
Sumatriptan is contraindicated in conditions like Diabetes mellitus,Hypertension,Myocardial infarction,Peripheral vascular disease,Ischaemic heart disease,Cerebrovascular accident,Prinzmetal's angina,Hepatic impairment,Coronary artery disease,Hypersensitivity.
Side Effects of Sumatriptan
The severe or irreversible adverse effects of Sumatriptan, which give rise to further complications include Tachycardia, Cardiac arrhythmias, Bradycardia, AV-block, Nystagmus, Seizures, Angina, Ventricular tachycardia, Ventricular fibrillation, Sinus bradycardia, Atrial fibrillation, Ischemic colitis, Syncope, Hypertensive crises, Myocardial infarction.,Sumatriptan produces potentially life-threatening effects which include Myocardial Ischemia. which are responsible for the discontinuation of Sumatriptan therapy.,The signs and symptoms that are produced after the acute overdosage of Sumatriptan include Diarrhea, Dyspnea, Myalgia.,The symptomatic adverse reactions produced by Sumatriptan are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Dizziness, Vertigo, Drowsiness, Fatigue, Palpitation, Pain, Irritation, Flushing, Diplopia, Nausea and vomiting, Muscle cramps, Tingling, Heaviness, Pressure or tightness in body parts, Heat sensation, Reduced vision, Flickering.
Precautions of Sumatriptan
Sumatriptan should be used with caution in patients with any pre-existing heart disease, coronary artery disease, high blood pressure, stroke, abnormal heart rhythm, kidney disease, liver disease or if have any allergy especially to sulfa drugs. Since this may cause drowsiness, use caution while driving or engaging in activities requiring alertness, avoid alcohol because it may increase drowsiness or dizziness effects. Sumatriptan should be used during pregnancy or lactation only when clearly needed. The drug should only be used where there is a clear diagnosis of migraine. Before treating headaches in patient not previously diagnosed as migrainures, and in migrainures who present with atypical symptoms, care should be taken to exclude other potentially serious neurological conditions. It should be noted the migranures may be at increasd risk of certain cerebrovascular events. The drug should be used with caution in the patient with the history of epilepsy or structural brain lesions which lower their convulsion threshold. The recommended dose of sumatriptan should not be exceeded.