Streptozotocin (Streptozotocin)
Overview of Streptozotocin
Streptozotocin is antineoplastic antibiotic derived from Streptomyces achromogenes or produced by chemical synthesis. Streptozotocin is the drug of choice in the of treatment of malignant pancreatic insulinomas and malignant carcinoid tumors (especially when given along with Fluorouracil). Streptozotocin is also effective in the treatment of Hodgkin`s disease and for colon cancer, when used in combination with other anticancer drugs.
Indication of Streptozotocin
Streptozotocin is primarily indicated in conditions like Islet cell pancreatic tumor, Pancreatic cancer.
Contraindication of Streptozotocin
Streptozotocin is contraindicated in conditions like Hypersensitivity to any component of product.
Side Effects of Streptozotocin
The severe or irreversible adverse effects of Streptozotocin, which give rise to further complications include Gi bleeding, Confusion, Pulmonary fibrosis, Increased intracranial pressure, Myocardial infarction, Brain neoplasm.,Streptozotocin produces potentially life-threatening effects which include Bone marrow suppression, Renal failure, Hepatic failure, Perforation of large intestine. which are responsible for the discontinuation of Streptozotocin therapy.,The symptomatic adverse reactions produced by Streptozotocin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Alopecia, Diarrhea, Fever, Urticaria, Hypotension, Tremor, Thrombophlebitis, StomatitisX, Slurred speech, Skin ulcers, Limb paresthesia.
Precautions of Streptozotocin
Streptozotocin is not recommended for use during pregnancy or lactation. Immunosuppressent drug should not be given, where possible, to patients with acute infection, dosage reduction or withdrawal should be considered if infection develops, until the infection has been controlled. Blood counts and measurement of hemoglobin concentration should be carried out routinely, help to predict the onset of bone marrow depression. It must be handled with great care and avoid contact with skin and eyes, and should not be inhaled. Avoid use in patient with impaired kidney or liver function.