Pyrimethamine (Pyrimethamine)
Overview of Pyrimethamine
Pyrimethamine is oral antimalarial agent. Pyrimethamine is a folic acid antagonist and dihydrofolate reductase inhibitor. Pyrimethamine is 2,4-diaminopyrimidine related to trimethoprim.
Indication of Pyrimethamine
Pyrimethamine is primarily indicated in conditions like Malaria, Malaria prophylaxis, Malaria treatment, Protozoa infection, Toxoplasmosis.
Contraindication of Pyrimethamine
Pyrimethamine is contraindicated in conditions like Anaemia.
Side Effects of Pyrimethamine
The severe or irreversible adverse effects of Pyrimethamine, which give rise to further complications include Megaloblastic anemia.,Pyrimethamine produces potentially life-threatening effects which include Agranulocytosis, Disseminated intravascular coagulation. which are responsible for the discontinuation of Pyrimethamine therapy.,The signs and symptoms that are produced after the acute overdosage of Pyrimethamine include Tachycardia, Coma, Fever, Blindness, Deafness, Dyspnea.,The symptomatic adverse reactions produced by Pyrimethamine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Rashes, Photosensitivity reactions.
Precautions of Pyrimethamine
Pyrimethamine should be used only if clearly needed during pregnancy or lactation. It should be used with caution in patients with any pre-existing kidney disease, liver disease, blood disorders or any allergy.