Propofol (Propofol)
Overview of Propofol
Propofol is extremely important intravenous anesthetic. Chemically Propofol is 2, 6-di-isopropylphenol. Propofol is chemically unrelated to other intravenous anesthetics. Propofol is used to induce anesthesia that can be maintained by continuous infusion or with inhalation anesthetics. It produces anesthesia at the rate similar to that of intravenous barbiturates, recovery is more rapid, and is associated with minimal postoperative confusion. Unlike many other general anesthetics, it possesses an antiemetic action. It received FDA approval in October 1989.
Indication of Propofol
Propofol is primarily indicated in conditions like Anesthesia, Induction of anaesthesia, Insomnia, Maintenance of anaesthesia, Sedation for surgical and diagnostic proceduers, Sedation in intensive care.
Contraindication of Propofol
Propofol is contraindicated in conditions like Disorders of fat metabolism.
Side Effects of Propofol
The severe or irreversible adverse effects of Propofol, which give rise to further complications include CNS depression, Transient bradycardia.,Propofol produces potentially life-threatening effects which include Cardiopulmonary depression. which are responsible for the discontinuation of Propofol therapy.,The symptomatic adverse reactions produced by Propofol are more or less tolerable and if they become severe, they can be treated symptomatically, these include Thrombophlebitis.
Precautions of Propofol
Propofol should be given with caution in patients with hypovolumia, epilepsy, lipid metabolism disorder, and in elderly. It should not be used with electroconvulsive therapy. Propofol is not recommended as an anaesthetic in children under 3 years of age.