Piperazine (Piperazine)
Overview of Piperazine
Piperazine is anthelmintic agent. Piperazine is available as hexahydrate and as a variety of salts such as citrate, phosphate, adipate, tartrate etc. Piperazine is used in the treatment of threadworms and round worms.
Indication of Piperazine
Piperazine is primarily indicated in conditions like Helminth infection.
Contraindication of Piperazine
Piperazine is contraindicated in conditions like Epilepsy,Impaired hepatic function,Impaired renal function.
Side Effects of Piperazine
Piperazine produces potentially life-threatening effects which include Ataxia, Clonic convulsions, Muscle hypotonia, Somnolence, Impaired conciousness. which are responsible for the discontinuation of Piperazine therapy.,The signs and symptoms that are produced after the acute overdosage of Piperazine include Convulsions, Coma.,The symptomatic adverse reactions produced by Piperazine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Urticaria, Allergic reactions, GI upset, Purpura, Acute hepatitis, Acute hemolysis.
Precautions of Piperazine
The drug should be used with extreme caution in renal or hepatic impairment and in seizures.