Piperacillin Na (Piperacillin Na)
Overview of Piperacillin Na
Piperacillin (Na) is a parenteral, semisynthetic, extended-spectrum acylureidopenicillin. Extended-spectrum penicillins, such as piperacillin, are used mainly in the treatment of serious, gram-negative infections and in combination with an aminoglycoside to treat systemic Pseudomonas infections. Clinically, piperacillin is used to treat intra-abdominal infections, respiratory and urinary tract infections, skin and soft-tissue infections, and other infections caused by susceptible organisms. Piperacillin was approved by the FDA in 1981. its patent expired in September 1995. Piperacillin is a ß-lactam antibiotic and is mainly bactericidal. It inhibits the third and final stage of bacterial cell wall synthesis by preferentially binding to specific penicillin-binding proteins (PBPs) that are located inside the bacterial cell wall. Penicillin-binding proteins are responsible for several steps in the synthesis of the cell wall and are found in quantities of several hundred to several thousand molecules per bacterial cell. Penicillin-binding proteins vary among different bacterial species.
Indication of Piperacillin Na
Piperacillin Na is primarily indicated in conditions like Bacterial infections, Bone and joint infection, Complicated appendicitis, GI infections, Gonorrhoea, Hodgkin's disease, Meningitis, Respiratory tract infections, Septicaemia, UTI.
Contraindication of Piperacillin Na
No data regarding the contra indications of Piperacillin (Na) is available.
Side Effects of Piperacillin Na
The severe or irreversible adverse effects of Piperacillin (Na), which give rise to further complications include Prolongation of bleeding time.,Piperacillin (Na) produces potentially life-threatening effects which include Anaphylaxis. which are responsible for the discontinuation of Piperacillin (Na) therapy.,The symptomatic adverse reactions produced by Piperacillin (Na) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Diarrhea, Thrombophlebitis.
Precautions of Piperacillin Na
Piperacillin should be used with caution in patients with any other illness or any allergy especially to penicillin or other antibiotics. It should be used only if clearly needed during pregnancy or lactation.