Phenytoin Na (Phenytoin Na)
Overview of Phenytoin Na
Phenytoin (Na) is oral and parenteral hydantoin anticonvulsant first synthesized in 1908. Although it has been used in many diverse conditions, its only approved use is as an anticonvulsant, specifically, for the prophylactic management of tonic-clonic seizures and partial seizures with complex symptomatology. Anticonvulsant drugs can elevate the seizure threshold and/or limit the spread of seizure discharge. Phenytoin exerts its anticonvulsant effect mainly by limiting the spread of seizure activity and reducing seizure propagation, unlike phenobarbital and carbamazepine, which elevate the seizure threshold. Phenytoin was originally approved by the FDA in 1939.
Indication of Phenytoin Na
Phenytoin Na is primarily indicated in conditions like Convulsions, Epilepsy, Migraine prophylaxis, Myotonia, Prophylaxis of epilepsy, Status epilepticus, Status epilepticus; seizures in neurosurgery, TIC douloureaux, Ventricular arrhythmias.
Contraindication of Phenytoin Na
Phenytoin (Na) is contraindicated in conditions like Porphyrias.
Side Effects of Phenytoin Na
The severe or irreversible adverse effects of Phenytoin (Na), which give rise to further complications include Ataxia, Nausea, Vomiting, Hypotension, Drowsiness, Nystagmus, Coma, Hyperglycemia, Stupor, Blurred vision.,Phenytoin (Na) produces potentially life-threatening effects which include Hepatitis, Dermatitis. which are responsible for the discontinuation of Phenytoin (Na) therapy.,The signs and symptoms that are produced after the acute overdosage of Phenytoin (Na) include Death.,The symptomatic adverse reactions produced by Phenytoin (Na) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Skin rashesX, Elevated alkaline phosphatase, Folate deficiency, Hypocalcemia.
Precautions of Phenytoin Na
Phenytoin should be used with caution in patients with liver, lungs, heart diseases and blood disorders. Perform blood counts before initiating the therapy. Administer cautiously in the presence of advanced atrioventricular (AV) block. Do not exceed an I/V infusion rate of 50mg/min. Discontinue use if skin rashes appear.