Perphenazine (Perphenazine)
Overview of Perphenazine
Perphenazine is a phenothiazine similar to chlorpromazine, used in the treatment of anxiety, psychotic disorders, confusion and agitation.
Indication of Perphenazine
Perphenazine is primarily indicated in conditions like Bipolar disorders, Mania, Nausea and vomiting, Psychosis, Schizophrenia, and can also be given in adjunctive therapy as an alternative drug of choice in Post-operative nausea and vomiting.
Contraindication of Perphenazine
Perphenazine is contraindicated in conditions like Blood dyscrasias,Bone marrow depression,Coma,Brain damage,Subcortical brain damage,Pregnancy,Breast feeding,Hypersensitivity to any component of product.
Side Effects of Perphenazine
The severe or irreversible adverse effects of Perphenazine, which give rise to further complications include Tachycardia, Cardiac arrhythmias, Urticaria, Hypotension, Jaundice, Extrapyramidal symptoms, Numbness, Gynacomastia, Dystonia, Slurred speech, Trismus, Retrocollis, Motor restlessness, Aching, Hyperreflexia, Anaemia.,Perphenazine produces potentially life-threatening effects which include Coma, Neuroleptic Malignant Syndrome, Stupor, Extrapyrimidal symptoms. which are responsible for the discontinuation of Perphenazine therapy.,The signs and symptoms that are produced after the acute overdosage of Perphenazine include Hypotension, Tachycardia, Confusion, Hypotonia, Hypothermia, Miosis, Tremor, Restlessness.,The symptomatic adverse reactions produced by Perphenazine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Constipation, Dry mouth, Blurred vision, Pain, Sedation, Miosis, Mydriasis.
Precautions of Perphenazine
Perphenazin should be used with caution or not at all in patients with impaired liver, kidney, cardiovascular, cerebrovascular, and respiratory function and in those with angle-closure glaucoma, a history of jaundice, parkinsonism, diabetes mellitus, hypothyroidism, myasthenia gravis, paralytic ileus, prostatic hyperplasia, or urinary retention. Care is required in patients with epilepsy or a history of seizures. Regular eye examinations are advisable for patients receiving long-term Perphenazine Enantate and avoidance of undue exposure to direct sunlight is recommended. Should be used with caution in the presence of acute infection or leucopenia. Blood counts are advised if the patient develops an unexplained infection or fever. Generally not recommended late in pregnancy; such use may be associated with intoxication of the neonate. Photosensitization may occur, caution patients against exposure to sunlight or UV light. Discontinue use at least 48 hrs. before myelography.