Pentobarbitone Na (Pentobarbitone Na)
Overview of Pentobarbitone Na
Pentobarbitone (Na) is a barbiturate, used as a sedative or hypnotic and as a pre-anesthetic drug.
Indication of Pentobarbitone Na
Pentobarbitone Na is primarily indicated in conditions like Insomnia, and can also be given in adjunctive therapy as an alternative drug of choice in Raised intracranial pressure.
Contraindication of Pentobarbitone Na
Pentobarbitone (Na) is contraindicated in conditions like Pain,Pulmonary insufficiency,Porphyria,Sleep apnea syndrome.
Side Effects of Pentobarbitone Na
The severe or irreversible adverse effects of Pentobarbitone (Na), which give rise to further complications include Ataxia, Fever, Angioneurotic edema, Skin reactions, Sedation, Megaloblastic anemia, Myalgia, Neuralgia, Arthritic pain, Slurred speech.,Pentobarbitone (Na) produces potentially life-threatening effects which include Carcinogenicity, Impaired conciousness. which are responsible for the discontinuation of Pentobarbitone (Na) therapy.,The signs and symptoms that are produced after the acute overdosage of Pentobarbitone (Na) include Bradycardia, Hypotension, Coma, Respiratory depression, Hypothermia, Miosis, Renal failure, Oliguria, Shock, CNS depression, Hyper-reflexia, Cardiac depression, Pupillary constriction.,The symptomatic adverse reactions produced by Pentobarbitone (Na) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Drowsiness, Excitement, Nausea, Confusion, VertigoX, Sedation, Photosensitivity, Unsteadiness, Loss of memory.
Precautions of Pentobarbitone Na
Pentobarbitone should not be used in patients with bronchopneumonia or status asthmaticus because it could increase respiratory depression. The drug should be used cautiously in patients with major depression or suicidal ideation, because the CNS-depressant effects of the drug can exacerbate the condition. Because of reduced renal or hepatic function, geriatric patients may require reduced doses. Pentobarbital should be used cautiously in patients with uncontrolled acute or chronic pain, with renal and the hepatic disease. It should be used with caution in patients who must perform hazardous tasks because depression of the CNS can produce effects of drowsiness and loss of mental alertness.Pentobarbitone, administered parenterally, should be used with caution in cases of hypotension, pulmonary disease, or cardiovascular disease because of possible adverse hemodynamic effects. IV administration can cause respiratory depression and should be administered slowly to avoid hypotension. It should not be prescribed in high doses for prolonged use because of the potential for psychological and physical dependence. It should not recommended for use during pregnancy because fetal abnormalities have been reported. Use of pentobarbitone in the third trimester can result in physical dependence in the neonate. If used during labor, neonates should be carefully observed for signs of respiratory depression. Premature babies are particularly sensitive to respiratory depression. Caution should be done in administering these drugs to patients with skin disease who may be predisposed to allergic reactions. Pentobarbitone is excreted into breast milk and can cause CNS depression in infants of breast-feeding mothers.Tolerance and physiological dependence can occur with pentobarbitone. Abrupt discontinuation of prolonged barbiturate therapy can result in withdrawal symptoms.