Nifurtimox (Nifurtimox)
Overview of Nifurtimox
Nifurtimox is the first compound that proved effective in human therapy of the South American trypanosomiasis caused by Trypanosoma cruzi. Chemically itidentified as 3-methyl-N-[(5-niro-2-furanyl) methylene]-4-thiomorpholinamine-1, 2-dioxide. Nifurtimox is tripanocidal against both amastigote and tripomasigote form of Trypanosoma cruzi. iteffective against both acute as well as chronic phase of infection. it is prepared by chemical synthesis. itadministerd orally.
Indication of Nifurtimox
Nifurtimox is primarily indicated in conditions like Leishmaniasis, Onchoceriasis, Trypanosomiasis.
Contraindication of Nifurtimox
Nifurtimox is contraindicated in conditions like Convulsions,Cerebral impairment.
Side Effects of Nifurtimox
The severe or irreversible adverse effects of Nifurtimox, which give rise to further complications include Convulsions, Insomnia, Psychosis, Disorientation, Disturbance of equilibrium.,Nifurtimox produces potentially life-threatening effects which include Leucopenia. which are responsible for the discontinuation of Nifurtimox therapy.,The signs and symptoms that are produced after the acute overdosage of Nifurtimox include Excitation, Gastralgia.,The symptomatic adverse reactions produced by Nifurtimox are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Vomiting, Anorexia, Myalgia, Urticaria, Skin rash, Paresthesias, Neuralgia, Morbiliform, Exanthema, dizziness.
Precautions of Nifurtimox
The drug should be used with extreme caution in the pregnant or the breast feeding women and children <1year old.