Nalidixic Acid (Nalidixic Acid)
Overview of Nalidixic Acid
Nalidixic Acid is antibacterial of quinolone group. It was introduced in 1963. Nalidixic Acid is non-fluorinated urinary antiseptic to which resistnce readily occurs. Nalidixic Acid is effective in uncomplicated urinary-tract infections. May cause gastro-intestinal symptoms and allergic reactions.May exacerbate epilepsy and respiratory depression.
Indication of Nalidixic Acid
Nalidixic Acid is primarily indicated in conditions like Bacterial infections, GI infections, Long-term treatment of healed gastro-oesophageal reflux disease, Muscle relaxation (long duration) for surgery and intubation, Urinary tract infection, and can also be given in adjunctive therapy as an alternative drug of choice in Shigellosis.
Contraindication of Nalidixic Acid
Nalidixic Acid is contraindicated in conditions like Epilepsy,Convulsions,Hypersensitivity.
Side Effects of Nalidixic Acid
The severe or irreversible adverse effects of Nalidixic Acid, which give rise to further complications include Thrombocytopenia, Cholestatic jaundice, Hemolytic anemia, Cholestatic jaundice, Hemolytic anemia, Photosensitivity, Eosinophilia, Eosinophilia, Leucopenia, Raised intracranial pressure, Hemolytic anemia, Arthralgia.,Nalidixic Acid produces potentially life-threatening effects which include Anaphylaxis. which are responsible for the discontinuation of Nalidixic Acid therapy.,The signs and symptoms that are produced after the acute overdosage of Nalidixic Acid include Disorientation, Nausea, Drowsiness, Drowsiness, Hallucinations, Ataxia, Hyperglycemia, Light headedness, Teichopsia, Hyperpnea, Glycosuria.,The symptomatic adverse reactions produced by Nalidixic Acid are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Vertigo, Drowsiness, Nausea, Vomiting, Wakness, Urticaria, Pruritus, GI upset, Muscular weakness, dizziness.
Precautions of Nalidixic Acid
Nalidixic acid should be used with caution in patients with any pre-existing kidney disease, liver disease, seizure disorder, nervous system disorder or any allergies especially allergies to antibiotics. It should be use with caution while driving or performing tasks requiring alertness, because it may cause dizziness or lightheadedness. Limit alcohol intake. Because this medication increases sensitivity to the sun, avoid prolonged sun exposure, wear protective clothing and use a sunscreen when outdoors. It should be used with caution during pregnancy or lactation.