Mitomycin C (Mitomycin C)
Overview of Mitomycin C
Mitomycin C is a cell cycle-phase nonspecific antineoplastic. Mitomycin is a natural product obtained from Streptomyces caespitosus and is used in the treatment of stomach, pancreatic, breast, colon, head, neck, and lung cancers. Adenocarcinomas of the gastrointestinal tract are particularly sensitive. Mitomycin is an atypical alkylating agent. Mitomycin C is unique for its delayed and deep myelosuppression. There are no other drugs similar to mitomycin on the market. Mitomycin is sometimes referred to as MMC or mitomycin C. Mitomycin was approved by the FDA in 1974. Mitomycin must be metabolized by hepatic microsomal enzymes to be active. The metabolite is an alkylating agent that binds to DNA. RNA usually is not affected. Mitomycin is also capable of creating oxygen free radicals, which damage DNA. The alkylating activity, however, causes the most damage. Both mechanisms lead to interference in DNA replication, transcription of RNA, and nucleic acid function, and both activities contribute to cell death.
Indication of Mitomycin C
Mitomycin C is primarily indicated in conditions like Bladder carcinoma, Breast cancer, Cervical carcinoma, Lung cancer, Stomach cancer, Upper gastro-intestinal and breast cancer, and can also be given in adjunctive therapy as an alternative drug of choice in Colon tumor, Pancreatic tumour, Pancreatic tumour, Soft tissue sarcoma.
Contraindication of Mitomycin C
Mitomycin C is contraindicated in conditions like Myelosuppression.
Side Effects of Mitomycin C
The severe or irreversible adverse effects of Mitomycin C, which give rise to further complications include Renal damage, Thrombocytopenia, Leucopenia, Diffused pulmonary infiltration.,Mitomycin C produces potentially life-threatening effects which include Bone marrow, Suppression, Hemolytic anemia, Hemolytic anemia. which are responsible for the discontinuation of Mitomycin C therapy.,The signs and symptoms that are produced after the acute overdosage of Mitomycin C include Severe myelosuppression.,The symptomatic adverse reactions produced by Mitomycin C are more or less tolerable and if they become severe, they can be treated symptomatically, these include Alopecia, Diarrhea, Stomatitis, Nausea and vomiting, Alopecia, Cellulitis.
Precautions of Mitomycin C
Mitomycin C must not be used during pregnancy or lactation. It should be used with caution in patients with any pre-existing blood disorder, kidney disease or any allergy.