Methyprylone (Methyprylone)
Overview of Methyprylone
Chemically Methyprylone is 3, 3-diethyl-5-methyl-2, 4-piperidinedione. Methyprylone is oral hypnotic and used in the management of insomnia of varied etiology.
Indication of Methyprylone
Methyprylone is primarily indicated in conditions like Insomnia.
Contraindication of Methyprylone
Methyprylone is contraindicated in conditions like Alcohol dependence,Depression,Porphyria,Sleep apnea syndrome.
Side Effects of Methyprylone
The severe or irreversible adverse effects of Methyprylone, which give rise to further complications include Hallucinations, Anxiety, Polyuria, Seizures, Dependence, Hyperreflexia.,Methyprylone produces potentially life-threatening effects which include Pulmonary edema, Coma, Respiratory depression, Hypotension. which are responsible for the discontinuation of Methyprylone therapy.,The signs and symptoms that are produced after the acute overdosage of Methyprylone include Coma, Hyperthermia, Respiratory depression, Pupillary changes, Hypothermia, Nystagmus, Dysarthria.,The symptomatic adverse reactions produced by Methyprylone are more or less tolerable and if they become severe, they can be treated symptomatically, these include GI disturbance, CNS disturbances.
Precautions of Methyprylone
Patient should observe caution while driving or performing other task requiring alertness because it may produce dizziness. Total daily intake should not exceed to 400 mg. Methyprylone should be used with caution in patients with kidney and liver disease. Perform periodic blood counts if use over prolonged period. Patients should be warned against the concomitant use of methyprylone and alcohol or other CNS depressants. Habituation and physical dependence have been reported to occur when excessive doses are taken over an extended period of time.