Melarsoprol (Melarsoprol)
Overview of Melarsoprol
Melarsoprol is antprotozoal drug, used in the treatment of advanced african trypanosomiasis with CNS involvement, but it has replaced other arsenicals for this purpose.
Indication of Melarsoprol
Melarsoprol is primarily indicated in conditions like Trypanosomiasis.
Contraindication of Melarsoprol
Melarsoprol is contraindicated in conditions like Viral infection.
Side Effects of Melarsoprol
The severe or irreversible adverse effects of Melarsoprol, which give rise to further complications include Liver damage, Jarisch herxheimer reaction, Jaundice, Jaundice, Thrombophlebitis, Erythema, Coma, Albuminuria, Urinary casts.,Melarsoprol produces potentially life-threatening effects which include Agranulocytosis, Thrombocytopenia, Aplastic Anemia, Encephalopathy, Exfoliative dermatitis, Aplastic anemia, Peripheral neuropathy. which are responsible for the discontinuation of Melarsoprol therapy.,The symptomatic adverse reactions produced by Melarsoprol are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Fever, Abdominal pain, Urticaria, Arthralgia, Nausea and vomiting, Slurred speech, Erythematous rash, Abdominal colic, Convulsions, Limb pain, Erythematous rash.
Precautions of Melarsoprol
Melarsoprol should be used with extreme caution in patients with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency. It should not be administered during epidemics of influenza. Malaria or pneumonia should be treated before administration of melarsoprol. Patient should be in hospital when they are treated with melarsoprol. It should be used with caution during pregnancy.