Megestrol acetate (Megestrol acetate)
Overview of Megestrol acetate
Megestrol is a sex hormone orally active synthetic derivative of progeterone, actions and effects are similar to that of progesterone. Used to suppress oestrogen-dependent tumours of the breast and the uterus by interferingwith uptake of oestrogen into the tumours. Chemically Megestrol (Acetate) is identified as 17-hydroxy-6-methylpregne-4,6-diene-3, 20-dione acetate. Adverse effects include weight gain, hair loss, deep venous thromboses in the legs.
Indication of Megestrol acetate
Megestrol Acetate is primarily indicated in conditions like Breast cancer, Prostatic cancer, and can also be given in adjunctive therapy as an alternative drug of choice in Cancer cachexia, Endometrial cancer, Renal carcinoma.
Contraindication of Megestrol acetate
Megestrol (Acetate) is contraindicated in conditions like Diabetes mellitus,Dysfunctional uterine bleeding,Vaginal bleeding,Thrombophlebitis.
Side Effects of Megestrol acetate
The severe or irreversible adverse effects of Megestrol (Acetate), which give rise to further complications include Hypertension, Pulmonary embolism, Heart failure, Deep vein thrombosis.,The symptomatic adverse reactions produced by Megestrol (Acetate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Alopecia, Urticaria, Weight gain, Edema, Hot flushes, Increased appetite, Carpal tunnel syndrome, Hyperglycemia, Mood changes, Tumor flare.
Precautions of Megestrol acetate
Megestrol should be used with caution in patients with liver disease, depression, incomplete abortion, unusual vaginal bleeding, suspected pregnancy, blood clotting problems and of any allergy. Contraceptive (birth control) measures are recommended for use in men and women while taking this medication. Megestrol is not recommended for use during pregnancy or lactation.