Kanamycin (Acid Sulphate) (Kanamycin (Acid Sulphate))
Overview of Kanamycin (Acid Sulphate)
Bactericidal aminoglycoside antibiotic (the aminoglycosides are the compound containing characteristic amino sugars joined to a hexose nucleus in glycoside linkage, they are polycations and their polarity accounts for their pharmakokinetic peoperties). Kanamycin (Acid Sulphate) is derived from Streptomyces kanamyceticus, consisting of three components designated A, B and C. The clinically active form is a mixture of kanamycins A and B. Kanamycin has actions and spectrum similar to Neomycin, but less ototoxic. Used in gram -ve speticaemia, with monitoring of blood levels, perticularly in renal failure. Kanamycin (Acid Sulphate) is most often applied topically.
Indication of Kanamycin (Acid Sulphate)
Kanamycin (Acid Sulphate) is primarily indicated in conditions like Bacterial infections, Enteritis, Gonorrhoea, Hepatic encephalopathy, Meningitis, Septicaemia, Tuberculosis, Urinary tract infection, and can also be given in adjunctive therapy as an alternative drug of choice in Superficial infections.
Contraindication of Kanamycin (Acid Sulphate)
Kanamycin (Acid Sulphate) is contraindicated in conditions like Neuromuscular blockade.
Side Effects of Kanamycin (Acid Sulphate)
The severe or irreversible adverse effects of Kanamycin (Acid Sulphate), which give rise to further complications include Nephrotoxicity, Ototoxicity, Eosinophilia, Eosinophilia.,Kanamycin (Acid Sulphate) produces potentially life-threatening effects which include Neuromuscular blockage. which are responsible for the discontinuation of Kanamycin (Acid Sulphate) therapy.,The signs and symptoms that are produced after the acute overdosage of Kanamycin (Acid Sulphate) include 8th nerve damage.,The symptomatic adverse reactions produced by Kanamycin (Acid Sulphate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Vertigo, Headache, Nausea, Vomiting, Diarrhea, Tinnitus, Local pain, Circumoral paresthesia, Bruising, Bruising.
Precautions of Kanamycin (Acid Sulphate)
Kanamycin should be used with caution in patients with history of kidney diseases gasteointertinal ulceration, vertigo, hearing loss, mysthenia gravis, parkinsonisms.It should be used with caution in patients who are sensitive to aminoglycosides. Keep patients well hydrated to prevent chemical irritation or nephrotoxic reactions. Take appropriate measures in case of secondry infections.