Isotretinoin (Isotretinoin)
Overview of Isotretinoin
Isotretinoin is the 13-cis-retinoic acid, a vitamin A derivative, used systematically for treatment of severecystic and conglobulate acne acne not responsive to antibiotic therapy. Thought to act directly on sebaceous glands in the skin to reduce sebum production and alters the lipid composition of the skin surface.
Indication of Isotretinoin
Isotretinoin is primarily indicated in conditions like Gram negative folliculitis, Keratiniztion disorders, Mild acne in patients with dysmorphohobia, Rosacea, Severe acne.
Contraindication of Isotretinoin
Isotretinoin is contraindicated in conditions like Hypersensitivity.
Side Effects of Isotretinoin
The severe or irreversible adverse effects of Isotretinoin, which give rise to further complications include Thrombocytopenia, Hepatitis, Myalgia, Hypercholesterolemia, Hypercholesterolemia.,Isotretinoin produces potentially life-threatening effects which include Depression. which are responsible for the discontinuation of Isotretinoin therapy.,The symptomatic adverse reactions produced by Isotretinoin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Alopecia, Abdominal pain, Blurred vision, Arthralgia, Erythematous rash, Cheilitis, Conjunctivitis, Nasal bleeding, Photophobia, Skin sepsis, Desquamation, Facial dermatitis, Epistaxis, Paronychia, Blepharoconjunctivitis, Alopecia, Erythematous rash, Pruritis, Skin fragility, Hearing impairment, Impaired night vision.
Precautions of Isotretinoin
Isotretinoin should be used with caution in patients with medical history, including diabetes, family history of high blood fats (triglycerides), depression or any allergy (including drugs e.g. Tetracyclines). Do not donate blood while taking isotretinoin and for at least one month after stop taking it. Avoid exposure to the sun and sunlamps use a sunscreen and wear protective clothing when exposed to direct sunlight. Isotretinoin can affect night vision. Be cautious when driving or operating any machinery after dark. Avoid the use of alcohol while taking this. It should not be used during pregnancy or lactation. Do not apply isotretinoin gel to your lips, mouth and mucous membrane or in the angle of your nose.