Isocarboxazid (Isocarboxazid)
Overview of Isocarboxazid
Isocarboxazid is antidepressant and belongs to monoamino oxidase inhibitors. It forms stable complexes with the enzyme, causing irreversible inactivation.This results in increased stores of norepinephrine, serotinin and dopamine within the neuron and subsequent diffusion of excess neurotransmitter into synaptic space.Isocarboxazid is used to treat depression in patient who are unresponsive to tricyclic antidepressant. Isocarboxazid is also used in the treatment of phobic states.
Indication of Isocarboxazid
Isocarboxazid is primarily indicated in conditions like Anxiety, Depression, Narcolepsy, Obsessive-compulsive disorders, Panic disorders, Phobias.
Contraindication of Isocarboxazid
Isocarboxazid is contraindicated in conditions like Phaeochromocytoma,Cardiovascular disease,Cerebrovascular disease.
Side Effects of Isocarboxazid
The severe or irreversible adverse effects of Isocarboxazid, which give rise to further complications include Hypertensive crises.,Isocarboxazid produces potentially life-threatening effects which include Purpura, Granulocytopenia. which are responsible for the discontinuation of Isocarboxazid therapy.,The signs and symptoms that are produced after the acute overdosage of Isocarboxazid include Hypotension, Tachycardia, Convulsions, Coma, Respiratory depression, Pyrexia, Ataxia, Dizziness, Respiratory depression, Irritability, Mental confusion, Respiratory depression.,The symptomatic adverse reactions produced by Isocarboxazid are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Dizziness, Constipation, Dry mouth, Blurred vision, Peripheral edema, Edema, Orthostatic hypotension, Slow micturition, Postural dizziness, Dry mouth, Oedema, dizziness, Weakness.
Precautions of Isocarboxazid
Take adequate precautions when treating epileptic patients. Isocarboxazid should be used with caution in patients with impaired renal (kidney) function and hyperthyroidism. Perform periodic liver function tests, discontinue use at the first sign of hepatic (liver) dysfunction or jaundice.