Indapamide (Indapamide)
Overview of Indapamide
Indapamide is antihypertensive agent. It was synthesized in 1969. Indapamide is the first of a new class of diuretic or antihypertensives, the indolines. It increases the urination and reduces the amount of water and sodium retained by the body. its diuretic effects is similar to that induced by thiazides. Chemically Indapamide is identified as 3-(aminosulfonyl) -4-chloro-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)-benzamide hemihydrate. Indapamide is a 2-methyl indoline derivative of 4-chloro-3-sulfamoyl benzoyl benzamide and differ from the classic Thiazides in lacking a benzothiadiazine hetrocycle and in contaning only one sulfamoyl group.
Indication of Indapamide
Indapamide is primarily indicated in conditions like Essential hypertension, Hypertension, Oedema in congestive heart failure, Oedema in pregnancy.
Contraindication of Indapamide
Indapamide is contraindicated in conditions like Renal failure,Hepatic failure,Hypersensitivity.
Side Effects of Indapamide
The severe or irreversible adverse effects of Indapamide, which give rise to further complications include Hypokalemia, Hypercalcemia, Increased BUN (blood urea nitrates), Hyperuricemia, Hypoglycemia, Flaccid paralysis.,Indapamide produces potentially life-threatening effects which include Coma, Cardiac Arrest, Cardiac arrest. which are responsible for the discontinuation of Indapamide therapy.,The signs and symptoms that are produced after the acute overdosage of Indapamide include Respiratory depression, Hypokalemia, Respiratory depression, Nausea & vomiting, Hyperuricemia, Muscle fatigue, Weakness, Respiratory depression, Acute gout.,The symptomatic adverse reactions produced by Indapamide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Fatigue, Fever, Blurred vision, Skin rash, Agitation, Lassitude, Bleeding, dizziness.
Precautions of Indapamide
Use indapamide, with caution in patients with history of heart rhythm problems, diabetes, gout, kidney, thyroid, parathyroid or liver disease, systemic Lupus erythematosus (SLE) or an allergy to sulfa drugs. Indapamide should not be used during pregnancy or lactation. It should be used with caution in patients with high blood pressure. Electrolyte imbalance should be corrected before the administration of indapamide. Elderly Should take low dose.