Imipramine Hcl (Imipramine Hcl)
Overview of Imipramine Hcl
Imipramine Hcl was recognized as an antidepressant in 1950s and is the prototype drug of tricyclic antidepressants of the class dibenzazepine class. Tricyclic antidepressant is used for almost four decades. Chemically itclosely related to the phenothiazines. itthe first of the tricyclic antidepressants to be used. Imipramine Hcl has characteristic three ring nucleus. itprepared by chemical synthesis. italso used in the treatment of childhood enuresis, anxiety in panic syndrome, and chronic pain.
Indication of Imipramine Hcl
Imipramine Hcl is primarily indicated in conditions like Anorexia nervosa, Attention deficit disorders, Bulimia nervosa, Depression, Enuresis, Headache, Hyperactivity, Hypercalcaemia, Neuropathic pain, Neurosis, Obsessional states, Osteolytic lesions, Pain, Panic disorders, Phobias.
Contraindication of Imipramine Hcl
Imipramine (HCl) is contraindicated in conditions like Epilepsy,Mania,Prostatic hypertrophy,Narrow-angle glaucoma,Bundle branch block,Post myocardial infarction,Hypersensitivity,Urinary retention.
Side Effects of Imipramine Hcl
The severe or irreversible adverse effects of Imipramine (HCl), which give rise to further complications include Tachycardia, Oedema, Bundle branch blockage, Postural hypotension, Tachycardia.,Imipramine (HCl) produces potentially life-threatening effects which include Agranulocytosis. which are responsible for the discontinuation of Imipramine (HCl) therapy.,The signs and symptoms that are produced after the acute overdosage of Imipramine (HCl) include Hypotension, Tachycardia, Cardiac arrhythmias, Convulsions, Coma, Mydriasis, Hyperreflexia, Sinus tachycardia, hyperreflexia.,The symptomatic adverse reactions produced by Imipramine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Drowsiness, Fatigue, Restlessness, Constipation, Abdominal pain, Dry mouth, Blurred vision, Urticaria, Photosensitivity, Impotence, Sleep disturbance, Hypotension, Weight gain, Tremor, Hepatotoxicity, Impairment of memory, Agitation, Cutaneous vasculitis, Eosinophilia, Loss of accomodation, Leukopenia, Urinary hesitancy, Urinary RetentionX, Urinary retention, Increased anxiety, Delayed ejaculation, Enlarged prostate gland, Dry mouth.
Precautions of Imipramine Hcl
Imipramine HCl should be used with caution (if it contains tartrazine) in patients with aspirin hypersensitivity, because it may produce allergic reaction (including bronchial asthma). Monitor ECG before initiating large doses. Avoid concurrent administration with electric shock therapy because may increase the hazards of therapy. Perform periodic leukocytes (white blood cells) counts and liver function tests. Photosensitization may occur so caution patients to take protective measures sunscreen e.t.c. against exposure to UV light or sun light. Following prolong therapy in high doses, abrupt discontinuation should be avoided because it could precipitate the symptoms of cholinergic rebound such as nausea, vomiting and diarrhea. IM injection should be administered cautiously in the patient receiving imipramine.