Aprotinin (Aprotinin)
Overview of Aprotinin
Aprotinin is an antiplasmin agent i.e. haemostatic. Aprotinin is a serine protease inhibitor. Aprotinin is used in acute pancreatitis (infalmmation of pancrease), in the management of sudden bleeding episodes in haemophilias and other bleeding disorders.
Indication of Aprotinin
Aprotinin is primarily indicated in conditions like Abnormal blood loss prevention, Fat embolism syndrome, Hyperfibrionolytic haemorrhage, Hyperplasminaemia, Liver transplantation, Muscle relaxation (short to intermediate duration), Pancreatic and endotoxic shock, Pancreatitis, Ruptured intracranial aneurysm, Traumatic and haemorrhagic shock.
Contraindication of Aprotinin
Aprotinin is contraindicated in conditions like Hypersensitivity.
Side Effects of Aprotinin
The symptomatic adverse reactions produced by Aprotinin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Hypersensitivity reactions.
Precautions of Aprotinin
Aprotinin hypersensitivity should be tested prior to administration. All patients should receive a test dose to assess possible allergic reaction. Those who have had previous therapy with aprotinin should be treated with special caution to avoid a possible anaphylactic reaction. In patients being given a repeat dose of aprotinin, an H�-histamine antagonist can be administered before the loading dose. Safe use of aprotinin in children has not been established.