Flurazepam Hcl (Flurazepam Hcl)
Overview of Flurazepam Hcl
Flurazepam Hcl is a 1,4-benzodiazipine with long duartion of action. A substituent in the 7th position such as halogen or a nitro group is required for its sedative- hypnotic activity. Benzdiazipines are the most widely used anxiolytic drugs. The benzodiazipines are more effective and safer. They have largely replaced barbiturates and meprobamate in the treatment of anxiety.
Indication of Flurazepam Hcl
Flurazepam Hcl is primarily indicated in conditions like Hypnotic, Insomnia, Nausea, vertigo, labyrinthine disorders, NSAID-associated gastric and duodenal ulcers and duodenal errosions.
Contraindication of Flurazepam Hcl
Flurazepam (HCl) is contraindicated in conditions like Myasthenia gravis,Respiratory depression,Sleep apnea syndrome,Acute pulmonary insufficiency.
Side Effects of Flurazepam Hcl
The severe or irreversible adverse effects of Flurazepam (HCl), which give rise to further complications include Aggression, Anxiety.,Flurazepam (HCl) produces potentially life-threatening effects which include Anaphylactoid reactions. which are responsible for the discontinuation of Flurazepam (HCl) therapy.,The signs and symptoms that are produced after the acute overdosage of Flurazepam (HCl) include Drowsiness, Ataxia, Dysarthria.,The symptomatic adverse reactions produced by Flurazepam (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Drowsiness, Nausea, Constipation, Blurred vision, VertigoX, Hypotension, Light headedness, Slurred speech, Respiratory depression, Diminished libido, Feeling of hangover.
Precautions of Flurazepam Hcl
Patient should observe caution while driving or performing other task requiring alertness because it may produce dizziness. It should be used with caution in patients with respiratory disease, muscle weakness, history of drug or alcohol abuse, marked personality disorder; avoid regular use during pregnancy (risk of neonatal withdrawl symptoms); use only if clear indication such as seizure control (high doses during late pregnancy or labour may cause neonatal hypothermia, hypotonia and respiratory depression); breast-feeding (present in milk, avoid if possible); reduce dose in elderly and debilitated, and in hepatic (avoid if severe) and renal impairment (start with small doses if severe); avoid prolong use (abrupt withdrawl thereafter); porphyria. It should not be used alone to treat depression (or anxiety associated with depression) or psychosis