Fluphenazine (Fluphenazine)
Overview of Fluphenazine
Fluphenazine is antipsychotic drug, also called as neuroleptic drug. Fluphenazine is the 2-trifluromethyl derivative of perphenazine, the most potent of phenothiazine tranquilizers. Fluphenazine is effective in treatment of schizophrenia, manic states and delirium.
Indication of Fluphenazine
Fluphenazine is primarily indicated in conditions like Diagnostic procedures, Hypothyroidism, Mania, Muscle spasm of varied aeitology, Post-operative nausea and vomiting, Psychosis, Relief of discomfort in mild UTIs.
Contraindication of Fluphenazine
Fluphenazine is contraindicated in conditions like Blood dyscrasias,Hepatic disease,Coma,Brain damage.
Side Effects of Fluphenazine
The severe or irreversible adverse effects of Fluphenazine, which give rise to further complications include Tardive dyskinesia, Neurological disturbances.,Fluphenazine produces potentially life-threatening effects which include Blood dyscrasias, Malignant neuroplastic syndrome. which are responsible for the discontinuation of Fluphenazine therapy.,The signs and symptoms that are produced after the acute overdosage of Fluphenazine include Hypotension, Tachycardia, Hypothermia, Tachypnea.,The symptomatic adverse reactions produced by Fluphenazine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Allergic reactions, Skin pigmentation, Galactorrhea, HyperprolactinemiaX, Cholestatic Jaundice, Adverse behavioral reactions, Adverse neurological symptoms, ANS adverse effects, Deposits in lense & cornea.
Precautions of Fluphenazine
Fluphenazine should be used with caution in patients exposed to extreme heat or phosphorus insecticides, patients in state of alcohol withdrawal, patients with history of peptic ulcer, allergic reactions, with renal (kidney) impairment, prostatic hypertrophy. Photosensitization may occur, caution patients to take appropriate measures i.e. sunscreen e.t.c. against exposure to sunlight or UV light. Discontinue use atleast 48 hrs.before myelography.