Famotidine (Famotidine)
Overview of Famotidine
Famotidine was introduced in mid 1970s. Famotidine is a histamine H2 receptor blocker and inhibits secretion of gastric acid produced by histamine. itused to treat and prevent duodenal and peptic ulcers, zollinger-ellison syndrome (hypersecretion of HCl) to treat gastroesophageal reflux disorder (heart burn).
Indication of Famotidine
Famotidine is primarily indicated in conditions like Benign gastric and duodenal ulceration, Benign gastric ulcer, Duodenal ulceration, Duodenal ulcer, Duodenal ulcer relapse prophylaxis, Reflux oesophagitis, Zollinger-ellison syndrome, and can also be given in adjunctive therapy as an alternative drug of choice in Dyspepsia, Heart burn.
Contraindication of Famotidine
Famotidine is contraindicated in conditions like Hypersensitivity,Gastric malignancy.
Side Effects of Famotidine
Famotidine produces potentially life-threatening effects which include Blood dyscrasias. which are responsible for the discontinuation of Famotidine therapy.,The signs and symptoms that are produced after the acute overdosage of Famotidine include Hypotension, Tachycardia, Emesis, Restlessness.,The symptomatic adverse reactions produced by Famotidine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Diarrhea, Constipation, Bradycardia, Jaundice, Mental confusion, Hypotension, Renal failure, Epidermal necrolysis.
Precautions of Famotidine
Famotidine should be used with caution in patients with impaired kidney or liver function. Intravenous injection should be given slowly and intravenous infusion is recommended in patients with cardiovascular impairment.