Etidronate Disodium (Etidronate Disodium)
Overview of Etidronate Disodium
Etidronate is a diphosphonate compound, ethane-1-hydroxy-1,1-diphosphonate. It helps to maintain calcium levels and bone metabolism. Etidronate (Disodium) is used to treat osteoporosis and symptoms of paget's disease (bone weakening disease). Etidronate (Disodium) is also used after hip replacement or spinal cord injury.
Indication of Etidronate Disodium
Etidronate (Disodium) is primarily indicated in conditions like Bone (pagets) disease, Hypercalcaemia of malignancy, Postmenopausal osteoporosis.
Contraindication of Etidronate Disodium
Etidronate (Disodium) is contraindicated in conditions like Osteolytic paget's disease,Pregnancy,Breast feeding,Pain and inflammation (rheumatic disease),Vasomotor symptoms in estrogen deficiency, see instruction.
Side Effects of Etidronate Disodium
The severe or irreversible adverse effects of Etidronate (Disodium), which give rise to further complications include Hypersensitivity rashes.,Etidronate (Disodium) produces potentially life-threatening effects which include Worsening of Pre-existing renal impairment, Acute Renal Failure, Acute renal failure. which are responsible for the discontinuation of Etidronate (Disodium) therapy.,The signs and symptoms that are produced after the acute overdosage of Etidronate (Disodium) include Acute renal failure.,The symptomatic adverse reactions produced by Etidronate (Disodium) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Osteomalacia, Pathalogical fracture, Transient taste disturbances, Gastrointestinal Intolerance.
Precautions of Etidronate Disodium
Patients who are on calcium and vitamin D restriction may be more sensitive to the effects of etidronate. Patients should be sure to maintain appropriate dietary intake of vitamin D and calcium while receiving this medication. Etidronate can cause diarrhea, particularly when high doses are administered, and the drug should be used with caution, if at all, in patients with enterocoliti. It should be used with caution in patients with renal impairment or a decreased glomerular filtration rate. It should be used during pregnancy only if the potential benefits to the mother outweighs thepotential risks to the fetus.